Key result
Sumatriptan significantly mitigated cisplatin-induced renal injury in mice by inhibiting oxidative stress and enhancing antioxidant enzyme activities.
Why the study?
Given the anti-inflammatory and antioxidant properties of sumatriptan, this study explored its protective effects in mitigating cisplatin-induced nephrotoxicity.
Does sumatriptan ameliorate renal injury induced by cisplatin in mice?
Does sumatriptan ameliorate renal injury induced by cisplatin in mice?
p-value: p=<0.01
Sumatriptan mitigates cisplatin-induced renal injury in mice by inhibiting oxidative stress and enhancing antioxidant enzyme activities.
May support sumatriptan renoprotection in cisplatin regimens; hypothesis-generating from animal data only.
OBJECTIVES: Cisplatin (Cis) is an anticancer compound, which is used for the treatment of various cancers. Sumatriptan (Suma) is a selective agonist of 5-hydroxytryptamine 1B/1D (5HT1B/1D) receptor, which is prescribed for the management of migraine. It is well-established that Suma has anti-inflammatory and antioxidant properties. We have explored the protective effects of Suma in the mitigation of Cis-induced nephrotoxicity. MATERIALS AND METHODS: The mice received a single IP injection of Cis (20 mg/kg) on the first day of the experiment. Suma treatment (0.1 and 0.3 mg/kg/day, IP) was started on day 1 and continued for 3 consecutive days. RESULTS: Creatinine (Cr), blood urea nitrogen (BUN) and malondialdehyde (MDA) levels were elevated and glutathione peroxidase (GPx) as well as superoxide dismutase (SOD) activities were decreased in Cis-treated mice. Suma (more potently 0.3 mg/kg) reduced Cr, BUN and MDA levels and increased SOD and GPx levels. Suma also reduced the acute renal injury (tubular degeneration, tubular cells vacuolation, tubular necrosis and cast), which corresponded to kidney damage in Cis-treated mice. CONCLUSION: These findings demonstrate that Suma mitigates Cis-induced renal injury by inhibition of oxidative stress and enhancing the antioxidant enzymes activities.
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Bazmandegan et al. (2019) studied Cisplatin-induced nephrotoxicity (n=28). Sumatriptan vs. Cisplatin alone (20 mg/kg) was evaluated on Renal injury markers (Creatinine, BUN, MDA) and antioxidant enzyme activities (SOD, GPx) (p=<0.01). Sumatriptan significantly mitigated cisplatin-induced renal injury in mice by inhibiting oxidative stress and enhancing antioxidant enzyme activities.
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