Key result
Patients with slow coronary flow had significantly lower plasma nitric oxide levels compared to those with normal coronary flow (18.4 vs 25.2 µmol/L) and impaired flow-mediated dilatation.
Population
70 subjects who had undergone routine coronary arteriography, including 36 patients with slow coronary flow…
Design
Case-control, Two independent observers who were unaware of the clinical state…
Authors
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Lower nitric oxide and impaired FMD associate with slow coronary flow; hypothesis-generating and should not yet change practice.
Case-Control (n=70)
Yes
Absolute Event Rate: 18.4% vs 25.2%
p-value: p=0.001
Reduced plasma nitric oxide levels and impaired flow-mediated dilatation suggest that endothelial dysfunction plays a key role in the pathogenesis of the slow coronary flow phenomenon.
Sezgin et al. (2005) conducted a case-control in Slow coronary flow phenomenon (n=70). Slow coronary flow vs. Normal coronary flow was evaluated on Plasma nitric oxide (NO) level (p=0.001). Patients with slow coronary flow had significantly lower plasma nitric oxide levels compared to those with normal coronary flow (18.4 vs 25.2 µmol/L) and impaired flow-mediated dilatation.