Key result
ACE inhibitors are associated with a rare but potentially fatal side-effect of angioedema, with a reported worldwide incidence of 0.1-0.2%, though the incidence in South Africa remains unknown.
ACE inhibitors can cause fatal angioedema, a rare but severe side effect whose incidence in the South African population remains unknown.
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Clinicians should monitor South African patients on ACE inhibitors for angioedema; unknown local incidence leaves precise risk assessment open.
ACE inhibitors are often prescribed in the treatment of hypertension, heart failure and kidney disease. These drugs are on the Essential Drugs List, and are therefore used at primary to tertiary health care levels in South Africa. Angioedema is considered a rare, but potentially fatal side-effect of this agent, with a reported incidence of 0.1–0.2% worldwide.1 Its incidence in the South African population is, however, unknown.
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Tiemensma et al. (2010) studied Angioedema. ACE inhibitors was evaluated on Angioedema. ACE inhibitors are associated with a rare but potentially fatal side-effect of angioedema, with a reported worldwide incidence of 0.1-0.2%, though the incidence in South Africa remains unknown.
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