Key result
Quinidine at 1 x 10(-6) M or more dose-dependently decreased the transient outward current and accelerated its decay phase in rat hippocampal neurons, suggesting open channel blockade.
Why the study?
Does quinidine affect the transient outward current in rat hippocampal neurons?
Population
Dissociated hippocampal pyramidal neurons of rats
Design
Preclinical
Authors
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May underlie quinidine CNS effects via open-channel blockade in rats; leaves open human neuronal relevance and clinical translation.
Does quinidine affect the transient outward current in rat hippocampal neurons?
Quinidine dose-dependently decreases the transient outward current and accelerates its decay phase in rat hippocampal neurons, providing a potential mechanism for its central nervous system side effects.
Oyama et al. (1992) studied this question. Quinidine was evaluated on Transient outward current (IA). Quinidine at 1 x 10(-6) M or more dose-dependently decreased the transient outward current and accelerated its decay phase in rat hippocampal neurons, suggesting open channel blockade.
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