Nuclear translocation of human H-chain in its intact cage-like structure without any additional modifications enables a rapid nuclear delivery of an encapsulated anticancer drug (doxorubicin). This reduces the doses of drugs simultaneously bypassing the cellular multidrug resistance. Apoferritin exhibits synergistic effects through attenuating drug-induced dysregulation of the cellular iron. Tests on cerebellar organotypic cultures show the natural cell selectivity and drug accumulation in brain tissue.
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Zhang et al. (2015) studied this question.
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