Key result
A proposed linear extrapolation method reliably estimated the unloaded thickness of porcine aortic tissues, with no significant difference in thickness between 20x20 mm and 30x30 mm samples (median difference -0.095 mm, p=0.09).
Why the study?
Soft tissue sample thickness measurement is a major source of variation between mechanical responses reported across different groups.
A newly proposed force-driven method using linear extrapolation can quickly and reliably estimate the unloaded undeformed thickness of arterial tissues without relying on constitutive models.
Supports consistent ex vivo thickness measurement in porcine aortic tissues; leaves open applicability to human samples and clinical settings.
Soft tissue sample thickness measurement is one of the major sources of differences between mechanical responses published by different groups. New method for the estimation of unloaded sample thickness of soft tissues is proposed in this study. Ten 30 × 30 mm and ten 20 × 20 mm samples of porcine anterior thoracic aortas were loaded by gradually increased radial force. Their deformed thickness was then recorded in order to generate a pressure-thickness response. Next, the limit pressure to which the response can be considered linear was estimated. Line was fitted to the linear part of the curve and extrapolated towards zero pressure to estimate unloaded thickness (7 kPa fit). For comparison, data near zero pressure were fitted separately and extrapolated towards zero (Near Zero fit). The limit pressure for the linearity of the response was around 7 kPa. The Unloaded thickness for 30 × 30 mm samples was 2.68 ± 0.31 mm and 2.68 ± 0.3 mm for Near Zero fit and 7 kPa fit, respectively. The Unloaded thickness for 20 × 20 mm samples was 2.60 ± 0.35 mm and 2.59 ± 0.35 mm for Near Zero fit and 7 kPa fit, respectively. The median of thickness difference between smaller and larger samples was not found statistically different. Proposed method can estimate unloaded undeformed sample thickness quickly and reliably.
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Schwarz et al. (2023) studied None (experimental biomechanics on porcine aortas) (n=10). Linear extrapolation of pressure-thickness response (7 kPa fit) vs. Near Zero fit was evaluated on Unloaded thickness difference between 20x20 mm and 30x30 mm samples (Median difference -0.095 mm, p=0.09). A proposed linear extrapolation method reliably estimated the unloaded thickness of porcine aortic tissues, with no significant difference in thickness between 20x20 mm and 30x30 mm samples (median difference -0.095 mm, p=0.09).
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