What question did this study set out to answer?

To comprehensively catalogue extracellular leucine-rich repeat (eLRR) proteins across diverse species and assess their evolutionary divergence and developmental expression profiles.

September 14, 2007BMC GenomicsOpen Access

The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns

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Authors

JDJackie DolanTrinity College Dublin KWKaren WalsheTrinity College Dublin SASamantha AlsburyKing's College London

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Implication

Comparative genomic analysis reveals 369 extracellular leucine-rich repeat proteins across worms, flies, mice, and humans, highlighting conserved roles in neural development and immunity.

Key Points

To comprehensively catalogue extracellular leucine-rich repeat (eLRR) proteins across diverse species and assess their evolutionary divergence and developmental expression profiles.
Identified eLRR proteins in worms, flies, mice, and humans using transmembrane-prediction tools, motif-detection software, and the custom algorithm LRRscan.
Mapped evolutionary relationships and gene clustering through hierarchical clustering using TribeMCL.
Characterized spatial expression patterns of novel candidate genes in developing mouse and fly nervous systems.
Catalogued 369 total eLRR proteins (29 in worm, 66 in fly, 135 in mouse, and 139 in human), grouping them into distinct classes based on domain architecture.
Identified novel gene clusters, including two Elfn genes containing eLRR and fibronectin-type 3 domains and six transmembrane Elron genes containing only eLRRs.
Demonstrated discrete anatomical expression of novel eLRR genes in the embryonic fly nervous system and the developing mouse thalamus and cortex.

Cite This Study

Dolan et al. (2007) studied this question.

synapsesocial.com/papers/6a998798f4aef602fec72fb3 https://doi.org/10.1186/1471-2164-8-320

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Implication

Comparative genomic analysis reveals 369 extracellular leucine-rich repeat proteins across worms, flies, mice, and humans, highlighting conserved roles in neural development and immunity.

The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns

Discussion

Member takes

Implication

Key Points

Cite This Study

The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns

Discussion

Member takes

Implication

Key Points

Cite This Study

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