Taurolin, a New Chemotherapeutic Agent

Taurolin, bis‐(1,1‐dioxo‐perhydro‐1,2,4‐thiadiazinyl‐4)‐methan, is a novel, broad spectrum, non‐systemic chemotherapeutic agent. It is effective in vivo against a wide range of pathogenic organisms including Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris , and Salmonella typhimurium , and would be of particular use against antibiotic‐resistant organisms. It is based on an endogenous substance, taurine, which acts as a non‐toxic formaldehyde carrier donating methylol groups to bacterial protein and endotoxin thus causing denaturation and polycondensation of the pathogens and their pyrogens. It is anticipated that Taurolin will be of value in the treatment of faecal peritonitis.