Key result
Air pollution and environmental influences interact with susceptible genetic frameworks to drive the development and progression of cardiovascular disease.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Our findings help us to understand how it is that exposures to air pollution may cause the increases in heart attacks and strokes observed by other studies.”
“The study provides important new information on how pollution affects the main biological process that leads to heart disease.”
Review demonstrates accelerated atherosclerosis progression from air pollution exposure in genetically susceptible individuals, highlighting gene-environment risks.
It is an accepted biological premise that development of clinical cardiovascular disease is the result of gene–environment interactions: gene expression that leads to disease is the result of environmental influences in the setting of a susceptible genetic framework. Intensive efforts have gone
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Joel D. Kaufman (2010) studied this question. Air pollution and environmental influences interact with susceptible genetic frameworks to drive the development and progression of cardiovascular disease.
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