Radiosynthesis of tritium‐labeled novel nitromethylene neonicotinoids compounds with NaB3H4

Paichongding and Cycloxaprid are two novel neonicotinoids with good industrialization prospects for their high activity against imidacloprid‐resistant pest. In this paper, the radiosynthesis of [3H2]‐Paichongding and [3H2]‐Cycloxaprid was achieved using a NaB3H4 reduction. The title compounds were obtained with chemical purities of 98.7 and 98.4%, and radiochemical purities of 97.3 and 98.6%, respectively. The labeled compounds could be used as radiotracers for further study of metabolism and toxicology.