Agranulocytosis developed in 16 U. S. soldiers in Vietnam who were receiving daily dapsone prophylaxis for falciparum malaria. There were eight deaths in the group. All patients had been on prophylaxis from 3 weeks to 3 months. Recovery or death due to sepsis generally occurred within 9 days. The toxic effects of dapsone have resulted in a limitation in the use of dapsone for prophylaxis of falciparum malaria in U. S. troops in Vietnam.
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André J. Ognibene (1970) studied this question.
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