Why the study?
Does daily or alternate day rhDNase improve FEV1 and reduce costs compared to hypertonic saline in children with cystic fibrosis?
Population
48 children with cystic fibrosis
Comparison
Once daily 2.5 mg rhDNase or alternate day 2.5… vs Twice daily 5 ml 7% hypertonic saline for 12 weeks
Design
RCT, randomised, open
Follow-up
12 weeks
Authors
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Supports alternate-day rhDNase to reduce costs without losing FEV1 gains in pediatric CF; extends RCT evidence versus hypertonic saline.
Does daily or alternate day rhDNase improve FEV1 and reduce costs compared to hypertonic saline in children with cystic fibrosis?
In children with cystic fibrosis, alternate day rhDNase is as effective as daily rhDNase for improving FEV1 and offers potential cost savings compared to daily use, though both are more effective than hypertonic saline.
Ranjan Suri (2002) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: