PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications

Yuqing Peng; Huifang Zhao; Chenxin Yang; Xiangling Wang; Shuai Zhang

doi:10.34133/jbioxresearch.0037

January 1, 2025Journal of Bio-X ResearchOpen Access

PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications

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Key Points

Synthesize current evidence on the molecular mechanisms of PANoptosis and PANoptosome complexes in cancer to assess their prognostic and therapeutic potential.
Reviewed molecular components and regulatory functions of PANoptosis complexes, including ZBP1, RIPK1, AIM2, and NLRP12-PANoptosomes.
Assessed predictive PANoptosis-related gene signature models and pharmacological compounds capable of modulating cell death pathways.
Identified distinct PANoptosome complexes that simultaneously regulate apoptosis, necroptosis, and pyroptosis pathways during cancer progression.
Established that PANoptosis-based prognostic gene signatures accurately inform risk stratification and guide personalized treatment selection.
Summarized experimental compounds targeting PANoptosis signaling to alleviate drug resistance and counteract tumor-mediated immune evasion.

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Implication

Review highlights PANoptosome complexes and prognostic gene signatures in cancer, suggesting novel strategies to overcome drug resistance and immune evasion.

Abstract

PANoptosis has been shown to play important pathophysiological roles, particularly in cancer. This review summarizes the composition and functions of PANoptosis and its associated PANoptosomes, including the ZBP1, RIPK1, AIM2, and NLRP12-PANoptosomes. Predictive models based on PANoptosis markers have been developed to guide personalized treatment strategies, highlighting novel therapeutic targets. Research into compounds that modulate PANoptosis pathways is ongoing, with the aim of increasing cancer treatment efficacy and addressing challenges such as drug resistance and immune evasion. This review also summarizes innovative PANoptosis-related prognostic gene signature models and compounds that modulate PANoptosis pathways.

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Peng et al. (2025) studied this question.

synapsesocial.com/papers/6a99950587fa4c7a2056d1af https://doi.org/10.34133/jbioxresearch.0037

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PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications

Key Points

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Implication

Abstract

Discussion

Cite This Study

PANoptosis in Cancer: Molecular Mechanism, Current Evidence, and Therapeutic Implications

Key Points

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Implication

Abstract

Discussion

Cite This Study

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