What question did this study set out to answer?

To investigate the functional profile of follicular helper T-cell subsets in gastric cancer and examine their impact on humoral immunity and patient prognosis.

June 1, 2017Tumor BiologyOpen Access

Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer

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Authors

HZHong ZhangShanghai Chest Hospital RYRongxi Yue PZPengfei ZhaoSecond Affiliated Hospital of Zhejiang University

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Implication

Translational study reveals Th1-skewed follicular helper T cells promote inflammation and reduce survival in gastric cancer, highlighting a cellular driver of tumor progression.

Key Points

To investigate the functional profile of follicular helper T-cell subsets in gastric cancer and examine their impact on humoral immunity and patient prognosis.
Analyzed follicular helper T (Tfh) cell subsets in Helicobacter pylori–infected gastric cancer patients compared with asymptomatic H. pylori–infected individuals.
Assessed naive B-cell and Tfh-cell cocultures to evaluate antibody production, interferon-gamma signaling, and regulatory B-cell differentiation.
Evaluated the correlation between circulating Th1-Tfh cell frequencies and post-resection disease-free survival in gastric cancer patients.
Gastric cancer patients showed Tfh-cell skewing toward Th1 and Th17 subsets, with Th1-Tfh cells collaborating with other Tfh subsets to boost IgG secretion via interferon gamma.
Th1-Tfh cells actively inhibited the generation of protective interleukin-10+ regulatory B cells.
Higher frequencies of Th1-Tfh cells significantly correlated with reduced disease-free survival following surgical tumor resection.

Cite This Study

Zhang et al. (2017) studied this question.

synapsesocial.com/papers/6a9996452f144aa3941584b7 https://doi.org/10.1177/1010428317705747

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Implication

Translational study reveals Th1-skewed follicular helper T cells promote inflammation and reduce survival in gastric cancer, highlighting a cellular driver of tumor progression.

Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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