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The method of determination of mannitol used was that introduced by Smith, Finkelstein, and Smith (1), with modifications as indicated below. The method involves the oxidation of glucose-free filtrate with the reduction of a known excess of KIO, and quantitation of the re- maining KIO4 by iodometric titration with NaSO,.
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J. R. Elkinton (1947) studied this question.
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