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A novel azo-based near-infrared fluorescent theranostic probe was synthesized, which is selectively activated under hypoxic conditions, resulting in the release of an active anticancer drug and a near-infrared fluorophore turn-on. Notably, the probe has been applied successfully to real-time visualization of drug delivery in 4T1, HepG2 cells, and mice.
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Ding et al. (2019) studied this question.
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