Dapsone and Aplastic Anemia

Letters and Corrections1 January 1985Dapsone and Aplastic AnemiaJEAN FOUCAULD, M.D., WILLIAM UPHOUSE, M.D., JEFFREY BERENBERG, M.D.JEAN FOUCAULD, M.D.Search for more papers by this author, WILLIAM UPHOUSE, M.D.Search for more papers by this author, JEFFREY BERENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-139_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There are several reports of agranulocytosis and erythrocyte aplasia after administration of dapsone for treatment of leprosy and for prophylaxis against falciparum malaria (1, 2). We report what we believe is the first reported case of aplastic anemia due to administration of dapsone.A 18-year-old man from the island of Ponape (Eastern Caroline Islands) was diagnosed as having lepromatous leprosy on the basis of a hypoestetic macule on his chest. (A subsequent biopsy showed only tinea versicolor.) The patient was started on dapsone, 50 mg/d. Two weeks later, he developed a headache, runny nose, sore throat, dry...References1. NICHOLLSCONCANNON MA. Maloprim-induced agranulocytosis and red-cell aplasia. Med J Aust. 1982;2:564-6. CrossrefMedlineGoogle Scholar2. FIRKINMARIANI FA. Agranulocytosis due to dapsone. Med J Aust. 1977;2:247-51. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEAN FOUCAULD, M.D.; WILLIAM UPHOUSE, M.D.; JEFFREY BERENBERG, M.D.Affiliations: Tripler Army Medical Center Department of Surgery Honolulu, HI 96859 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDAPSONE INDUCED APLASTIC ANEMIA / DAPSON KAYNAKLI APLASTIK ANEMIDesign, Synthesis, and Molecular Modeling of Novel Pyrido[2,3- d ]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of HeterocyclesIdiosyncratic Drug Reactions and the Potential Role of MetabolismDetermination of dapsone in meat and milk by liquid chromatography tandem mass spectrometryMajor adverse effects from systemic drugs: Defining the risksDapsone-Induced Aplastic Anemia in a Woman With Bullous Systemic Lupus ErythematosusThe Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug Reactions 1 January 1985Volume 102, Issue 1Page: 139-139KeywordsAplastic anemiaBiopsyCandidaHeadachesLeprosyMalariaPharyngitisProphylaxisThorax ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...