Iron Responsive Thrombocytopenia

Letters1 May 1976Iron Responsive ThrombocytopeniaHOWARD SCHER, M.D., ROBERT SILBER, M.D.HOWARD SCHER, M.D.Search for more papers by this author, ROBERT SILBER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-571 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent experimental and clinical studies have provided evidence that iron has a role in the regulation of thrombopoiesis (1). Gross, Keffer, and Newman (2), studying 60 iron-deficient infants, noted the occurrence of thrombocytopenia and thrombocytosis. Both groups responded with a rise in platelet count, independent of hemoglobin level, after iron therapy. With further administration of iron, the platelet count stabilized at a normal level. In 1974, two cases have been reported that describe iron deficiency and thrombocytopenia corrected by parenteral iron administration (3, 4). Recently, we had the opportunity to study a polycythemic patient whose platelet count appeared sensitive to...References1. KARPATKINGARGFREEDMAN SSM: The role of iron as a regulator of thrombopoiesis. Am J Med 57:521-525, 1974 CrossrefMedlineGoogle Scholar2. GROSSKEFFERNEWMAN SVA: The platelets in iron deficiency anemia. I. The response to oral and parenteral iron. Pediatrics 34:315-323, 1974 Google Scholar3. SAHUDOLSENPEDEMONT MHL: Thrombocytopenia and iron deficiency. Ann Intern Med 81:132-133, 1974 LinkGoogle Scholar4. SONNEBORN D: Thrombocytopenia and iron deficiency (letter). Ann Intern Med 80:111, 1974 LinkGoogle Scholar5. FREEDMANKARPATKIN MS: Requirement of iron for platelet protein synthesis. Biochem Biophys Res Commun 54:475-481, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine New York University Medical Center New York, NY 10016 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThrombocytopenia in severe iron deficiency anemia in childrenAn analysis of the relationship between severe iron deficiency anemia and thrombocytopeniaAn Unusual Case of ThrombocytopeniaThrombopénie ferriprive : un diagnostic différentiel rare du purpura thrombopénique auto-immunThrombocytopenia in Children With Severe Iron DeficiencyNIron Deficiency and Megaloblastic AnemiasThrombocytopenia Associated with Repletion of Lron in Lron-Deficiency AnemiaSevere thrombocytopenia in iron deficiency anemiaThe Hematopoietic System 1 May 1976Volume 84, Issue 5Page: 571-572KeywordsHemoglobinInfantsIron deficiencyPlateletsThrombocytosis Issue Published: 1 May 1976 PDF DownloadLoading ...