In malarial hepatomegaly, sinusoidal dilatation is the most important factor contributing to the enlargement of the organ. Reticulo-endothelial hyperplasia and hypertrophy provide a minor contribution only. Chronic malaria provokes a slight degree of periportal fibrosis which, in the absence of liver cell damage, does not penetrate further into the substance of the lobule.
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Walters et al. (1960) studied this question.
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