Hyporeninemic Hypoaldosteronism

IT has been nearly 30 years since the first description of hyporeninemic hypoaldosteronism, by Hudson and colleagues, appeared in the pages of the Journal.1 In the case they described, plasma renin levels were not measured, but the patient had hyperkalemia and low levels of aldosterone in the urine. It was almost a decade before a second case was reported, and as recently as 10 years ago only 30 cases had been documented in the literature. The total has now risen to more than 100, including 7 reported in this issue.2 The first breakthrough in unraveling the pathophysiologic nature of . . .