Key result
Pressure indicators of left ventricular function correlated well with myocardial oxygen consumption during conditions of pulsatile support in calf experiments.
Why the study?
Do pressure indices of left ventricular function correlate with myocardial oxygen consumption during pulsatile ventricular assistance in an acute calf model?
Do pressure indices of left ventricular function correlate with myocardial oxygen consumption during pulsatile ventricular assistance in an acute calf model?
Left ventricular and intramyocardial pressure indices can reliably predict myocardial oxygen consumption during pulsatile ventricular assistance in an acute animal model.
Caution against clinical use of pressure indices for MVO2 estimation; leaves open validation beyond acute calf models.
Left ventricular (LVP) and intramyocardial (IMP) pressure indices were compared with left ventricular myocardial oxygen consumption (MVO2) during pulsatile ventricular assistance to determine if MVO2 can be predicted under conditions of ventricular support. During five acute anesthetized calf experiments, IMP and LVP were recorded for control and six conditions of support. The assisted conditions were asynchronous and synchronous, 1:1 or 1:2; each control mode with atrial uptake only or combined atrial and ventricular uptake. IMP was measured by implantation of a miniature pressure transducer in the midanteriolateral wall of the left ventricle. MVO2 was determined using the radioactive microsphere blood flow technique and blood gas data. Mean values of peak systolic pressure, maximum dP/dt, and Pdt were calculated for IMP and LVP for each condition. Pressure indicators of left ventricular function were found to correlate well with MVO2 during conditions of pulsatile support.
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Marks et al. (1989) studied Pulsatile ventricular assistance (n=5). Pulsatile ventricular assistance vs. Control mode was evaluated on Correlation of left ventricular (LVP) and intramyocardial (IMP) pressure indices with left ventricular myocardial oxygen consumption (MVO2). Pressure indicators of left ventricular function correlated well with myocardial oxygen consumption during conditions of pulsatile support in calf experiments.
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