New Promise for Vaccines against Tuberculosis

Tuberculosis has now exceeded infection with the human immunodeficiency virus and acquired immunodeficiency syndrome (HIV/AIDS) and malaria as the world’s largest cause of death from an infectious disease. The World Health Organization (WHO) estimates that there are 10.4 million new cases and 1.7 million deaths annually, including 0.4 million deaths in people with HIV infection, of which 95% occur in low-and-middle-income countries.1 The WHO End TB Strategy has set the ambitious target of reducing the incidence of tuberculosis disease by 90% by 2035. Yet since 2000, although global tuberculosis mortality has declined by 30%, the incidence of disease is being . . .