Urgent Treatment of Idiopathic Thrombocytopenic Purpura with Single-Dose Gammaglobulin Infusion Followed by Platelet Transfusion

Brief Reports1 June 1986Urgent Treatment of Idiopathic Thrombocytopenic Purpura with Single-Dose Gammaglobulin Infusion Followed by Platelet TransfusionMICHAEL A. BAUMANN, M.D., JAY E. MENITOVE, M.D., RICHARD H. ASTER, M.D., TOM ANDERSON, M.D.MICHAEL A. BAUMANN, M.D., JAY E. MENITOVE, M.D., RICHARD H. ASTER, M.D., TOM ANDERSON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-808 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntravenous administrations of high-dose gammaglobulin increases the peripheral blood platelet counts of most patients with idiopathic thrombocytopenic purpura (1-8). The mechanism of this effect has been thought to be a "blockade" by exogenous immunoglobulin of Fc receptors on phagocytic macrophages, with resultant inhibition of binding and removal from circulation of immunoglobulin-coated platelets (2, 8). Unfortunately, therapy as previously reported entails administration of a dose of 1.0 to 2.0 g/kg body weight given over 4 to 5 days (1-8), at a cost of approximately $6000 for a 5-day course in a person weighing 70 kg. Because responses are usually transient (1-8),...References1. IMBACHBARANDUND'APUZZO PSV. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet. 1981;1:1228-31. CrossrefMedlineGoogle Scholar2. FEHRHOFMANNKAPPELER JVV. Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin. N Engl J Med. 1982;306:1254-8. CrossrefMedlineGoogle Scholar3. SCHMIDTBUDDESCHAFERSTROEHMANN RUGI. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura [Letter]. Lancet. 1981;2:475-6. CrossrefMedlineGoogle Scholar4. ABRAMSASTERANDERSON RRT. Intravenous gammaglobulin in refractory immune thrombocytopenic purpura: efficacy with or without concomitant steroid therapy. Am J Hematol. 1985;18:85-9. CrossrefMedlineGoogle Scholar5. CARROLLNOYESKITCHENS RWC. High-dose intravenous immunoglobulin therapy in patients with immune thrombocytopenic purpura. JAMA 1983;249:1748-50. CrossrefMedlineGoogle Scholar6. CARROLLNOYESROSSEKITCHENS RWWC. Intravenous immunoglobulin administration in the treatment of severe chronic immune thrombocytopenic purpura. Am J Med. 1984;76:181-6. CrossrefMedlineGoogle Scholar7. ORALNUSBACHERHILLLEWIS AJJJ. Intravenous gamma globulin in the treatment of chronic idiopathic thrombocytopenic purpura in adults. AmJ Med. 1984;76:187-92. CrossrefMedlineGoogle Scholar8. BUSSELKIMBERLYINMAN JRR. Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura. Blood. 1983;62:480-6. CrossrefMedlineGoogle Scholar9. BUSSELGOLDMANIMBACHSCHULMANHILGARTNER JAPIM. Treatment of acute idiopathic thrombocytopenia of childhood with intravenous infusions of gammaglobulin. J Pediatr. 1985;106:886-90. 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Author, Article, and Disclosure InformationAffiliations: Medical College of Wisconsin and the Blood Center of Southeastern Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTransfusion Therapy in Specific Clinical SituationsProposal of treatment algorithm for immune thromocytopenia in adult patients of a hematology service at a referral center in Northeastern BrazilImmune ThrombocytopeniaPlatelet transfusion practices in immune thrombocytopenia related hospitalizationsGuidelines for the use of platelet transfusionsTransfusion Therapy in Specific Clinical SituationsPlatelet Disorders: Diagnostic Tests and Their InterpretationsClinical practice: immune thrombocytopenia in paediatricsThe Transfusion of Platelets, Leucocytes, Haematopoietic Progenitor Cells and Plasma ComponentsPlatelet transfusionPrimary Immune ThrombocytopeniaTransfusion Therapy in Specific Clinical SituationsOverview of Platelet TransfusionChildhood Immune Thrombocytopenic Purpura: Diagnosis and ManagementExperiences with recombinant FVIIa in the emergency treatment of patients with autoimmune thrombocytopenia: a review of the literatureChildhood Immune Thrombocytopenic Purpura: Diagnosis and ManagementTreatment of immune-mediated thrombocytopenia purpura with concurrent intravenous immunoglobulin and platelet transfusion: A retrospective review of 40 patientsPostnatal management of fetal and neonatal alloimmune thrombocytopenia: the role of matched platelet transfusion and IVIGCurrent Options for the Treatment of Idiopathic Thrombocytopenic PurpuraImmune Thrombocytopenic PurpuraHow I treat idiopathic thrombocytopenic purpura (ITP)Management of Adult Idiopathic Thrombocytopenic PurpuraAutoimmune and Hypersplenic CytopeniasChildhood Chronic Immune Thrombocytopenic Purpura: Unresolved IssuesIntracranial Hemorrhage in Immune Thrombocytopenic Purpura: A Retrospective AnalysisProphylactic platelet transfusions: which dose is the best dose? 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GALE, M.D., Ph.D.The nontreatment of childhood idiopathic thrombocytopenic purpura 1 June 1986Volume 104, Issue 6Page: 808-809KeywordsBlood countsBlood transfusionBody weightFc receptorsIdiopathic thrombocytopenic purpuraPlatelets Issue Published: 1 June 1986 PDF DownloadLoading ...