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A big “+”: The total synthesis of (−)-pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)-pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki–Hiyama–Kishi reaction to construct the (E)-cyclononene ring.
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Takao et al. (2008) studied this question.
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