Key result
Two children with early-onset hypotonia and paroxysmal dystonia, abolished by brief naps, presented a variant of alternating hemiplegia of childhood.
Case Report (n=2)
Alternating hemiplegia of childhood must be considered in the differential diagnosis of paroxysmal dystonia in childhood.
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Consider alternating hemiplegia of childhood in paroxysmal dystonia differentials; case reports extend the phenotype but leave prevalence and validation open.
We report 2 children with early onset of hypotonia and frequent episodes of paroxysmal dystonia. The episodes were abolished even by brief naps. One of the children developed alternating hemiplegia in the second decade. These children seem to have a variant of the now well-recognized syndrome of alternating hemiplegia of childhood. In that disorder, episodes of alternating hemiplegia develop before the age of 18 months. This syndrome must be considered in the differential diagnosis of paroxysmal dystonia in childhood.
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Andermann et al. (1994) conducted a case report in Infantile hypotonia and paroxysmal dystonia (n=2). Two children with early-onset hypotonia and paroxysmal dystonia, abolished by brief naps, presented a variant of alternating hemiplegia of childhood.
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