Painful Subcutaneous Hemorrhages of the Extremities with Unusual Reaction to Injected Deoxyribonucleic Acid

Case Studies1 May 1964Painful Subcutaneous Hemorrhages of the Extremities with Unusual Reaction to Injected Deoxyribonucleic AcidADAM S. LITTLE, M.D., F.R.C.P., HAROLD E. BELL, M.D.ADAM S. LITTLE, M.D., F.R.C.P.Search for more papers by this author, HAROLD E. BELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-886 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1961, Levin and Pinkus (1) reported the case of a 40-year-old Negro woman who for 4 years had suffered from acute and painful ecchymoses confined to her extremities. The lesions were preceded by a wheal which soon became hemorrhagic. The longest asymptomatic period in the 4 years had been 4 days. The intradermal injection of a solution of the patient's lysed leukocytes and a solution of deoxyribonucleic acid (DNA) obtained from calf thymus gland each produced hemorrhages in the skin of the extremities but failed to do so in the skin of the trunk. Similar injections using ribonucleic acid...References1. LEVINPINKUS MBH: Autosensitivity to deoxyribonucleic acid (DNA). New Eng. J. Med. 264: 533, 1961. CrossrefMedlineGoogle Scholar2. SCHWARTZLEWISDAMESHEK RSFBW: Hemorrhagic cutaneous anaphylaxis due to autosensitization to deoxyribonucleic acid. N. Eng. J. Med. 267: 1, 105, 1962. CrossrefMedlineGoogle Scholar3. COLTERBROWNELLEM JSRKA: Observation on the use of phenol for the isolation of deoxyribonucleic acid. Biochem et Biophys. Acta 55: 31, 1962. CrossrefMedlineGoogle Scholar4. KIDDTHOMAS HMJW: The level of vitamin B12 in circulating leukaemic leucocytes. Brit. J. Haemat., 8: 1, 64 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ADAM S. LITTLE, M.D., F.R.C.P.; HAROLD E. BELL, M.D.Affiliations: Edmonton, AlbertaFrom the University of Alberta Hospital, Edmonton, Alberta, Canada.Requests for reprints should be addressed to Adam S. Little, M.D., Suite C 133, University of Alberta Hospital, Edmonton, Alberta, Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPurpura and Microvascular OcclusionAutoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature**Dna autosensitivity in two japanese sistersPositive Nebenwirkungen antibiotischer bzw. antimikrobieller Substanzen in der TherapieAutosensitization to DNA: Evidence for an Immunologic BasisDrugs affecting blood clotting, fibrinolysis and haemostasisAUTDERYTHROCYTE SEXSITIZATION SYNDROME (PAINFUL BRUISING SYNDROME).Factitious Purpura Simulating Autoerythrocyte SensitizationROBERT M. LEVIN, M.D., RONALD CHODOSH, M.D., JOSEPH D. SHERMAN, M.D., PH.D.Intradermal Tests and Antinuclear Factors in Systemic Lupus Erythematosus A Comparative StudyFARIS J. AZOURY, M.D., HENRY E. JONES, M.D., VINCENT J. DERBES, M.D., F.A.C.P., OREN B. GUM, M.D., PH.D.Erythrocyte AutosensitizationThe Autologous Leukocyte Skin Test in Patients with Ulcerative Colitis 1 May 1964Volume 60, Issue 5Page: 886-891KeywordsDeoxyribonucleaseDNAHemorrhageIntradermal injectionsLesionsResearch laboratoriesRNAThymusTransplantation ePublished: 1 December 2008 Issue Published: 1 May 1964 PDF downloadLoading ...