Key result
The dominant rotavirus strain in Malaysian children with diarrhea shifted from G1P[8] (81%) in 1996 to G9P[8] (42%) in 2007, with no G9 strains detected in 1996.
Cross-Sectional (n=105)
Yes
The study demonstrates a shift in the dominant circulating rotavirus genotype in Malaysia from G1P[8] in 1996 to G9P[8] in 2007.
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Strain shifts in Malaysian rotavirus cases support ongoing local surveillance; leaves open vaccine effectiveness implications.
This study examined the temporal distribution of rotavirus genotypes in Malaysia. Rotaviruses from children with diarrhea admitted to hospitals in 1996 (n = 93) and 2007 (n = 12) in two different regions of Peninsular (West) Malaysia were analyzed for their G and P genotypes using a hemi-nested RT-PCR assay. In the 2007 samples, the dominant strain was G9P[8]. It was identified in 42% of the samples. Different strains all possessing the G1 genotype were identified in the rest of the samples. In contrast, 81% of the samples collected in 1996 were the G1P[8] strain. No strains with G9 genotype were detected in samples collected in 1996.
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Zuridah et al. (2010) conducted a cross-sectional in Diarrhea (Rotavirus) (n=105). Year of sample collection (2007) vs. Year of sample collection (1996) was evaluated on Rotavirus G and P genotypes. The dominant rotavirus strain in Malaysian children with diarrhea shifted from G1P[8] (81%) in 1996 to G9P[8] (42%) in 2007, with no G9 strains detected in 1996.
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