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125 M‐components of class γM in 123 sera have been typed with regard to light chain determinants K and L. The typing of most sera required initial isolation of 19 S‐fractions by thin layer gel filtration. 100 components were typed kappa and 25 lambda, giving a ratio of 4 to 1. Polyclonal γM from young adults contained kappa and lambda determinants in the ratio of 2 to 1. Possible explanations for this discrepancy are discussed.
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Wollheim et al. (1967) studied this question.
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