Cefoperazone and Prothrombin Time

Letters and Corrections1 May 1987Cefoperazone and Prothrombin TimeMYRON S. COHEN, M.D., H. E. WASHTON, M.D.MYRON S. COHEN, M.D.Search for more papers by this author, H. E. WASHTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-778_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article on the relationship between beta-lactam antibiotics and coagulopathy, Sattler and colleagues (1) cited our results (2) from a multicenter trial of cefoperazone sodium done in 1982 and 1983. We subsequently examined the effects of cefoperazone sodium on prothrombin time in greater detail (3). The trial included 894 patients. Most patients received 2 g of cefoperazone sodium twice per day. Data on prothrombin time was adequate for analysis in 695 (78%) of patients enrolled in the study. Prothrombin time was abnormal in 12 patients (1.7%) before therapy; was changed by less than 2 seconds during...References1. SATTLERWEITKAMPBALLARD FMJ. Potential for bleeding with new beta-lactam antibiotics. Ann Intern Med. 1986;105:924-31. LinkGoogle Scholar2. COHENWASHTONBARRANCO MHS. Multicenter trial of cefoperazone sodium in the United States. Am JMed. 1984;77(1B):35-41. Google Scholar3. COHENWASHTON MH. Effects of cefoperazone sodium on prothrombin time and clinical consequences (abstract 774). In: Proceedings of the IXth International Congress on Infectious and Parasitic Diseases. Munich, 1986. Google Scholar4. SATTLERCOLGOCAPUTOSCHOOLWERTH FDGA. Cefoperazone for empiric therapy in patients with impaired renal function. Am J Med. 1986;87:229-36. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCefoperazone plus tobramycin versus ticarcillin plus tobramycin in febrile granulocytopenic cancer patients 1 May 1987Volume 106, Issue 5Page: 778-778KeywordsAntibioticsCoagulopathyProthrombin timeSodium Issue Published: 1 May 1987 PDF downloadLoading ...