Key result
Methergine significantly increased the incidence of chest symptoms compared to control (30% vs 3.4%, P<0.05) during cesarean section, but this was not correlated with ischemic ECG changes.
Why the study?
Does methergine aggravate chest symptoms and/or ECG changes in women undergoing cesarean delivery under spinal anesthesia?
Observational (n=59)
Not blinded
Not randomized
No
Does methergine aggravate chest symptoms and/or ECG changes in women undergoing cesarean delivery under spinal anesthesia?
Intravenous methergine during cesarean delivery increases the incidence of chest symptoms without a corresponding increase in ischemic ECG changes.
Answers are grounded in this paper and cite their sources.
Chest symptoms with methergine in cesarean delivery may not signal ischemia; leaves open need for RCTs to guide use.
Background: Complaints of chest symptoms including pressure, tightness, or pain frequently occur during cesarean delivery under regional anesthesia. The aim of this study was to test whether methergine (methylergonovine maleate) aggravates chest symptoms and/or ECG changes during cesarean section under spinal anesthesia, and to determine if these changes are associated with any discernable intraoperative event.
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Hong et al. (2005) conducted an observational in Elective cesarean section (n=59). Methergine (methylergonovine maleate) vs. Oxytocin alone was evaluated on Incidence of chest symptoms (p=<0.05). Methergine significantly increased the incidence of chest symptoms compared to control (30% vs 3.4%, P<0.05) during cesarean section, but this was not correlated with ischemic ECG changes.
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