Key result
In patients with coronary artery disease, an ejection fraction <55% was associated with significantly lower flow-mediated vasodilation compared to an ejection fraction ≥55% (4.0% vs 4.8%; p<0.05).
Why the study?
Does left ventricular ejection fraction correlate with endothelial function in patients with coronary artery disease?
Cross-Sectional (n=283)
Does left ventricular ejection fraction correlate with endothelial function in patients with coronary artery disease?
Left ventricular ejection fraction is an independent parameter correlating with endothelial function in patients with coronary artery disease.
May link lower LVEF to endothelial dysfunction in CAD; leaves open causality and clinical utility pending prospective studies.
BACKGROUND: Endothelial dysfunction is present in patients with coronary artery disease (CAD) or with congestive heart failure. HYPOTHESIS: This study was performed to evaluate the impact of systolic heart function on endothelial function in patients with CAD. METHODS: The study population consisted of 283 consecutive patients (mean age 59 years, 176 men) undergoing coronary angiography. Endothelial function was assessed by measuring flow-mediated vasodilation (FMD) of the brachial artery. RESULTS: Patients (n = 236) with an ejection fraction (EF) > or = 55% on routine echocardiogram were younger (mean age 58 vs. 62 years), showed a lower prevalence of diabetes (15 vs. 38%) and myocardial infarction (13 vs. 66%), and showed a higher FMD (4.8 +/- 2.4 vs. 4.0 +/- 2.0%, p < 0.05) than patients (n = 47) with an EF < 55%. The correlation coefficient between FMD/endothelial function and EF/systolic heart function was 0.149 (p < 0.02) in the overall study population. Multivariate analysis showed that of age, gender, frequency of diabetes mellitus, myocardial infarction, and CAD extent, EF was the only significant independent parameter correlating with FMD in patients with CAD. CONCLUSIONS: Compared with the other tested risk factors, EF surprisingly was the only significant independent parameter correlating with endothelial function in patients with CAD. Our results support the view that endothelial function is an independent prognostic factor in patients with CAD.
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Bae et al. (2004) conducted a cross-sectional in Coronary artery disease (n=283). Ejection fraction < 55% vs. Ejection fraction ≥ 55% was evaluated on Endothelial function assessed by flow-mediated vasodilation (FMD) of the brachial artery (p=<0.05). In patients with coronary artery disease, an ejection fraction <55% was associated with significantly lower flow-mediated vasodilation compared to an ejection fraction ≥55% (4.0% vs 4.8%; p<0.05).
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