Key result
Contralateral carotid ligation increased intact carotid blood flow by 25% at 1 week and 45% at 5-6 months, while anastomosis increased flow by 76% and 89% at comparable periods.
Why the study?
Does contralateral carotid ligation or anastomosis alter carotid blood flow in anesthetized rats?
Does contralateral carotid ligation or anastomosis alter carotid blood flow in anesthetized rats?
Contralateral carotid ligation and anastomosis significantly increase blood flow through the intact carotid in a rat model.
Rat carotid flow rises after ligation or anastomosis; leaves open translation to human cerebrovascular interventions.
An experimental model was developed for continuous measurement of the common carotid blood flow, in the anesthetized rat, with an electromagnetic flowmeter. The mean carotid blood flow for 41 rats averaged 3.2 +/- 0.2 ml/min at an average mean arterial pressure of 101 +/- 2.5 mm Hg and arterial pO2 of 106 +/- 3.4 mm Hg, pCO2 of 38 +/- 1.2 mm Hg, and pH of 7.36 +/- 0.02. This model allowed short- and long-term carotid hemodynamic changes to be recorded after contralateral carotid ligation or end-to-side carotid anastomosis. After ligation of the contralateral carotid, blood flow through the intact carotid increased 25% (at about 1 week) and 45% (at about 5-6 months), whereas, after anastomosis, carotid blood flow increased 76% and 89% at periods comparable to those after ligation. Arterial pressure and gases did not change throughout the experimental periods. Probable mechanisms involved in these carotid hemodynamic changes are discussed.
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Garcı́a-Villalón et al. (1992) studied None (anesthetized rats) (n=41). Contralateral carotid ligation or end-to-side carotid anastomosis vs. Baseline was evaluated on Carotid blood flow. Contralateral carotid ligation increased intact carotid blood flow by 25% at 1 week and 45% at 5-6 months, while anastomosis increased flow by 76% and 89% at comparable periods.
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