Vein pouch and partial arteriotomy methods are the most satisfactory approaches for developing a laboratory model of intracranial aneurysms in rats.
May refine rat aneurysm models; leaves open clinical translation pending higher-level validation.
One hundred thirty-two experimental rat carotid artery aneurysms were produced using a variety of methods, in order to determine which of these approaches should be employed in the development of a satisfactory laboratory model. The gross appearance and pathomorphology of aneurysms created by vein pouch and partial arteriotomy methods most closely resembled those features reported in clinical intracranial aneurysms.
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Young et al. (1987) studied this question.
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