Key result
TGFβ signaling plays a highly contextual and critical role in cardiovascular diseases, acting as both a potential disease marker and therapeutic target.
This review highlights the complex, context-dependent role of TGFβ signaling in vascular biology and its potential as both a biomarker and therapeutic target in cardiovascular diseases.
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Cautions against broad TGFβ inhibition in cardiovascular disease; leaves open refined, context-dependent therapeutic approaches for future trials.
Transforming growth factor (TGF) family members are involved in a wide range of diverse functions and play key roles in embryogenesis, development and tissue homeostasis. Perturbation of TGF signaling may lead to vascular and other diseases. In vitro studies have provided evidence that TGF family members have a wide range of diverse effects on vascular cells, which are highly dependent on cellular context. Consistent with these observations genetic studies in mice and humans showed that TGF family members have ambiguous effects on the function of the cardiovascular system. In this review we discuss the recent advances on TGF signaling in (cardio)vascular diseases, and describe the value of TGF signaling as both a disease marker and therapeutic target for (cardio)vascular diseases.
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Pardali et al. (2012) conducted a review in Cardiovascular diseases. TGFβ signaling was evaluated. TGFβ signaling plays a highly contextual and critical role in cardiovascular diseases, acting as both a potential disease marker and therapeutic target.
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