Non‐Steroidal Antiinflammatory Agents, II1): Synthesis of Novel Pyrazole and Pyrazoline Derivatives of 4(3H)‐Quinazolinone Nicht‐steroidale Antiphlogistika, 2. Mitt.1): Synthese neuer Pyrazol‐ und Pyrazolin‐Derivate des 4(3H)‐Chinazolinons

Antiinflammatory and/or analgesic activities have been ascribed to compounds containing the 4(3H)-quinazolinone or pyrazole moiety. Continuation to the previous work in the field of the synthesis of non-steroidal antiinflammatory 4(3H)-quinazolinones, the present investigation deals with the synthesis of new compounds having the pyrazole or pyrazoline and 4(3H)-quinazolinone moieties in one molecule, hoping that such combination might improve their antiinflammatory activity. alpha,beta-unsaturated ketones when treated with hydrazine hydrate achieve cyclization to the corresponding pyrazoline derivatives, whereas, when arylhydrazines are used, pyrazole derivatives are formed.