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All articles of this category A novel synthesis of N -substituted-3-carboethoxymethylphthalimidines 5 is described from secondary benzamides. The benzamides 1 on lithiation with n -butyllithium followed by treatment with dimethylformamide furnish 3-hydroxyphthalimidines 2 in 74-84% yield. Phthalimidines 2 on reaction with phosphorane 3 , provide phthalimidines 5 in 67-95% yield, via esters 4 .
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MALI et al. (1986) studied this question.
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