The new purification method, alkylations and acylations of tuberculostatic antibiotic viomycin were performed. The characterizations were conducted with viomycin as well as the derivatives obtained by these reactions. And also it was clarified that the alkylations on the reactive hydroxyl group of tuberactidine function had no significant influence on the antimicrobial activities while, the acylations on the N-terminal amino functions nullified the potency.
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Kitagawa et al. (1972) studied this question.