Chemistry at the Uncertainty Limit This contribution is an extended version of a recent commentary published in Nature, in the new section Concepts.[1] The invitation by the Editor of Angewandte Chemie made me steer the piece towards chemistry questions and provide the experimental–theoretical bridge relevant to molecular dynamics.

Spatial and temporal resolution with, until recently, an unimaginable precision—about 0.01 Å and 10 fs, respectively—are today possible thanks to femtochemistry. However, this atomic-scale resolution raises fundamental questions from quantum mechanics: the Uncertainty Paradox. How is it that this is not an obstacle, and what are the future directions? are the themes of this Essay.