The results of a preliminary study on the biosynthesis of adrenocortical hormones by the human adrenal gland in vitro are presented. The substrates investigated were 3β-hydroxy-Δ5-pregnene-20-one, progesterone, 17α-hydroxyprogesterone, compound S (17α21-dihydroxy-Δ4-pregnene-3,20-dione) and deoxycorticosterone. The results have led to the proposal of the following tentative scheme of adrenocortical biosynthesis by the human adrenal:
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Lombardo et al. (1959) studied this question.
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