Key result
Loss of the AE3 Cl-/HCO3- exchanger in mouse hearts led to differential expression of hypoxia, angiogenesis, and energy metabolism genes, indicating it contributes to active CO2 disposal.
Population
AE3-null and wild-type mouse hearts (n=4 for each genotype)
Comparison
Loss of AE3 Cl-/HCO3- exchanger (AE3-null mice) vs Wild-type (WT) mice
Design
Preclinical
Authors
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AE3 loss alters cardiac gene expression in mice; hypothesis-generating for CO2 handling and requires human validation.
RNA Seq analysis of AE3-null mouse hearts reveals gene expression changes consistent with a hypoxia response and altered energy metabolism, supporting the hypothesis that AE3 contributes to active transport-mediated CO2 disposal in the heart.
Vairamani et al. (2017) studied Normal cardiac physiology / AE3-null (n=8). AE3 ablation (AE3-null) vs. Wild-type (WT) was evaluated on Differential gene expression (RNA Seq). Loss of the AE3 Cl-/HCO3- exchanger in mouse hearts led to differential expression of hypoxia, angiogenesis, and energy metabolism genes, indicating it contributes to active CO2 disposal.
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