Key result
General and epidural anesthesia significantly prolonged the pulse transit time difference between toe and finger compared to preinduction (from 70.9 ms to 106.4 ms, p<0.05), though the measure remained highly dependent on blood pressure changes.
Why the study?
Does the difference in pulse transit time between toe and finger (PTTt-f) serve as a blood pressure-independent parameter of arterial compliance during general and epidural anesthesia?
Observational (n=18)
No
Does the difference in pulse transit time between toe and finger (PTTt-f) serve as a blood pressure-independent parameter of arterial compliance during general and epidural anesthesia?
Absolute Event Rate: 106.4% vs 70.9%
p-value: p=<0.05
The difference in pulse transit time between the toe and finger (PTTt-f) is not independent of blood pressure changes during general and epidural anesthesia, limiting its utility as a pure measure of arterial compliance.
PTTt-f remains BP-dependent during anesthesia and should not yet guide compliance assessment; leaves open validation as an independent marker.
Background: Pulse wave velocity (PWV) and pulse transit time (PTT) are influenced by the arterial wall stiffness and compliance. Also, the PTT is dependent on blood pressure changes that can be accompanied by the anesthesia. The simply measured PTT has difficult to discriminate the arterial compliance changes from blood pressure changes. Therefore, we investigated that the differences of PTT between toe and finger as an independent parameter on blood pressure. Methods: Eighteen patients scheduled for elective lower abdominal gynecologic surgery were studied. General anesthesia was achieved with sevoflurane and epidural block was done with 0.2% ropivacaine and fentanyl 100μg via epidural catheter inserted into L1-L2 epidural space. PTT was measured in a finger (PTTf) and a toe (PTTt) by the time difference between the ECG R wave and the pulse wave of PPG. Blood pressure and PTT was measured at three instances such as preinduction (Pre), 5 minutes after intubation (Int5) and 30 minutes after injection of epidural dose (Epi). The time delay of PTT between toe and finger (PTTt-f) was measured. Results: PTTf and PTTt was prolonged at Int5 and Epi. But the PTTt-f was not different between the Int5 and Epi because of prolonged PTTf caused by the blood pressure decrement after the epidural block. Conclusions: PTTf, PTTt and PTTt-f can be a one of the convenient measurement of the arterial compliance but it was suggested that there need to be a parameter less dependent on the blood pressure changes. (Korean J Anesthesiol 2007; 53: 21~6)
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Kim et al. (2007) conducted an observational in Elective lower abdominal gynecologic surgery (n=18). General anesthesia and epidural block vs. Preinduction baseline was evaluated on Difference of pulse transit time between toe and finger (PTTt-f) (p=<0.05). General and epidural anesthesia significantly prolonged the pulse transit time difference between toe and finger compared to preinduction (from 70.9 ms to 106.4 ms, p<0.05), though the measure remained highly dependent on blood pressure changes.
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