Key result
Endomyocardial biopsy monitoring of 63 heart transplant recipients identified cytomegalovirus infection in 32 patients and recorded 22 deaths during follow-up.
Observational (n=63)
No
Endomyocardial biopsy remains a crucial tool for diagnosing post-transplant complications such as rejection and cytomegalovirus infection, guiding targeted immunosuppressive therapy.
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Biopsy CMV detection in small transplant cohort warrants clinical caution; leaves open whether routine monitoring improves outcomes.
Endomyocardial biopsy, first introduced in the posttransplant monitoring protocol by Billingham from Standford University, has become a necessity in the histological diagnosis, especially after the introduction of immunosuppressive treatment. Rejection is histologically illustrated by the occurrence of an interstitial and/or perivascular lymphocytic inflammatory infiltrate which, in severe cases, is associated with significant myocyte damage. In certain situations, the acute rejection is followed by irreversible damage, leading to patient’s death..
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Adriana Habor (2019) conducted an observational in Heart transplant (n=63). Endomyocardial biopsy monitoring was evaluated. Endomyocardial biopsy monitoring of 63 heart transplant recipients identified cytomegalovirus infection in 32 patients and recorded 22 deaths during follow-up.
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