Why the study?
Cardiac involvement in eosinophilic granulomatosis with polyangiitis is increasingly recognized, but it is unusual as the initial presentation.
Case Report (n=1)
No
This case demonstrates that eosinophilic granulomatosis with polyangiitis can present as acute myocardial infarction with non-obstructive coronary arteries, highlighting the diagnostic value of cardiac magnetic resonance imaging and the efficacy of immunosuppressive therapy.
ardiac involvement in eosinophilic granulomatosis with polyangiitis (EPGA) is increasingly recognized, but it is unusual to be the initial presentation.We report a case of vasculitic myocardial infarction (MI) and cardiogenic shock in an elderly man caused by EPGA.A 73-year-old man presented with acute chest pain radiating to back for two days.He has a history of asthma and allergic rhinitis for more than ten years well controlled by inhaled corticosteroid.The electrocardiogram showed sinus rhythm, right bundle-branch block and anterolateral ST-segment depression.He had elevated troponin T of 548 ng/L (reference: < 14 ng/L), creatine kinase of 454 IU/L (reference: 39-308 IU/L), white blood cell count of 13.8 × 10 9 /L (reference: 3.7-9.3× 10 9 /L) and eosinophil count of 12.4 × 10 9 /L (reference: 0.0-0.6 × 10 9 / L).Antineutrophil cytoplasmic, anti-extractable nuclear antigen, and anti-nuclear antibodies were negative.The evolution of laboratory parameters is shown (Figure 1).Transthoracic echocardiogram showed reduced left ventricular ejection fraction of 40%, anterolateral hypokinesia and 1 cm pericardial effusion near left ventricular apex.
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Shing Ching (2024) conducted a case report in Myocardial infarction and cardiogenic shock caused by eosinophilic granulomatosis with polyangiitis (EPGA) (n=1). High dose steroid and rituximab was evaluated on Clinical recovery and left ventricular ejection fraction.
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