July 20, 2004Diabetic Medicine
The metabolic syndrome and coronary heart disease in older women: findings from the British Women's Heart and Health Study
Key result
Metabolic syndrome was highly prevalent in older British women and significantly associated with prevalent coronary heart disease (WHO definition OR 1.45; 95% CI 1.19-1.75).
Why the study?
Is metabolic syndrome associated with prevalent coronary heart disease in older British women?
Population
3770 women aged 60-79 years randomly selected from 23 British towns
Comparison
Metabolic syndrome defined by modified WHO… vs Absence of metabolic syndrome
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Association in older women does not support practice change; leaves open incremental value over single components.
Study Design
Type
Cross-Sectional (n=3,770)
Multicenter
Yes
Structured PICO
Is metabolic syndrome associated with prevalent coronary heart disease in older British women?
P
Population
3,770 women aged 60-79 years randomly selected from 23 British towns to assess the association between metabolic syndrome and coronary heart disease.
E
Exposure
Metabolic syndrome defined by modified WHO criteria or ATP III criteria
C
Comparator
Absence of metabolic syndrome
O
Outcome
Prevalent coronary heart disease (CHD)hard clinical
Main Result
Odds Ratio: 1.45 (95% CI 1.19–1.75)
Both the modified WHO and ATP III definitions of metabolic syndrome are similarly associated with prevalent coronary heart disease in older women, though single components carry similar risk.
Cite This Study
Lawlor et al. (2004) conducted a cross-sectional in Metabolic syndrome and coronary heart disease (n=3,770). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Prevalent coronary heart disease (CHD) (OR 1.45, 95% CI 1.19-1.75). Metabolic syndrome was highly prevalent in older British women and significantly associated with prevalent coronary heart disease (WHO definition OR 1.45; 95% CI 1.19-1.75).