Tunable thermo-responsive polymer–protein conjugates via a combination of nucleophilic thiol–ene “click” and SET-LRP

Herein we report the synthesis of a protein macroinitiator in a one-pot strategy using phosphine-mediated thiol–ene “click”, the macroinitiator was used to polymerise ethylene glycol containing monomers to yield polymer–protein conjugates with tunable thermoresponsive behaviour.