Key result
A 65-year-old male developed fatal malignant hyperthermia (42°C) following neck-clipping of an aneurysm, likely due to synergistic effects of a hypothalamic hemorrhage and pre-existing myopathy.
Case Report (n=1)
This case report describes a fatal instance of malignant hyperthermia potentially triggered by the synergistic effects of a hypothalamic hemorrhage and pre-existing myopathy.
May warrant vigilance for malignant hyperthermia in neurosurgical patients with hypothalamic hemorrhage and myopathy; leaves open causal confirmation.
A report is made of a 65-year-old male who died of a malignant hyperthermia of 42 degrees C. Symptoms included muscle rigidity at the termination of operation for neck-clipping of an aneurysm of the anterior communicating artery. Latent myopathy was observed in skeletal muscle, and a bleeding focus was present in the left anterior region of the hypothalamus, coinciding with the temperature regulation center. The mechanism of onset of this disease is still poorly understood, but it seems that this disease occurred due to synergic effects of the hypothalamic hemorrhage and the pre-existing myopathy. The serum CPK level at the time of death was abnormally high (250 U), and 3.4% of isozyme CPK1 was detected. The serum myoglobin was 204, 850 ng/ml, a markedly high level, and myoglobinuric nephrosis was present as a result.
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Ohmori et al. (1982) conducted a case report in Malignant hyperthermia (n=1). Neck-clipping of an aneurysm was evaluated on Death from malignant hyperthermia. A 65-year-old male developed fatal malignant hyperthermia (42°C) following neck-clipping of an aneurysm, likely due to synergistic effects of a hypothalamic hemorrhage and pre-existing myopathy.
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