Key result
Intranasal inoculation of cats with picornavirus resulted in mild rhinitis, conjunctivitis, palatine or glossal ulcerations in 17%, and early bronchopneumonia with later epithelial proliferation.
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Provides feline model for picornavirus respiratory effects; leaves open relevance to spontaneous disease or other species.
SUMMARY Cats inoculated intranasally with an aerosol of picornavirus developed a clinically recognizable disease entity. In addition to developing mild rhinitis and conjunctivitis, 17% of the cats had palatine or glossal ulcerations (or both). Viral antigen was seen by fluorescent antibody techniques at the margins of the ulcers. The significant lesions were bronchopneumonia which occurred early in the disease and profiferation of alveolar and bronchiolar epithelium in an “adenomatoid” manner which occurred later. Viral antigen in reactive cells in the lung was demonstrated by fluorescent antibody techniques. Spleens in 20% of the cats had transverse dark bands not previously reported.
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Holzinger et al. (1970) studied Picornavirus Infection. Intranasal inoculation with an aerosol of picornavirus was evaluated on Pathologic features and clinical disease. Intranasal inoculation of cats with picornavirus resulted in mild rhinitis, conjunctivitis, palatine or glossal ulcerations in 17%, and early bronchopneumonia with later epithelial proliferation.
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