Stimuli-Responsive Luminescent Copper Nanoclusters in Alginate and Their Sensing Ability for Glucose

Visually observable pH-responsive luminescent materials are developed by integrating the properties of aggregation-induced emission enhancement of Cu nanoclusters (NCs) and the Ca 2+ -triggered gelatin of alginate. Sodium alginate, CaCO 3 nanoparticles, and Cu NCs are dispersed in aqueous solution, which is in a transparent fluid state, showing weak photoluminescence (PL). The introduced H + can react with the CaCO 3 nanoparticles to produce free Ca 2+, which can cross-link the alginate chains into gel networks. Meanwhile, a dramatic increase in the PL intensity of Cu NCs and a blue shift in the PL peak appeared, assigned to the Ca 2+ -induced enhancement and gelatin-induced enhancement, respectively. Their potential application as a sensor for glucose is also demonstrated based on the principle that glucose oxidase can recognize glucose and produce H +, which further triggers the above-mentioned two-stage enhancement. A linear relationship between the PL intensity and the concentration of glucose in the range of 0.1–2.0 mM is obtained, with the limit of detection calculated as 3.2 × 10 –5 M.