A Novel Method for Preparation of Ansapeptides; Synthesis of Model Peptide Alkaloids

The preparation of 14-membered peptide alkaloids was first investigated on model educts such as the pentafluorophenyl esters (1), Z = benzyloxycarbonyl. On the basis of these investigations it was subsequently possible to develop a method for the synthesis of dihydrozizyphin G (2), AA = CH2CH2, as the first compound of this type.