Key result
The CD36 C/C genotype with moderate meat consumption increased colorectal cancer risk compared to the A/A genotype with low meat consumption (OR 8.30; 95% CI 2.15-32.00).
Why the study?
Does the interaction between the CD36 gene A52C polymorphism and meat consumption increase the risk of colorectal cancer in Japanese individuals?
Population
366 Japanese individuals, comprising 128 hospital-based colorectal cancer cases and 238 non-cancer controls.
Comparison
CD36 gene A52C polymorphism combined with… vs CD36 gene A52C polymorphism combined with low…
Design
Case-control
Authors
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Should not yet change dietary advice; hypothesis-generating for CD36-meat interaction in colorectal cancer.
Case-Control (n=366)
Does the interaction between the CD36 gene A52C polymorphism and meat consumption increase the risk of colorectal cancer in Japanese individuals?
Odds Ratio: 8.3 (95% CI 2.15–32)
The interaction between moderate meat consumption and the CD36 gene A52C polymorphism (C/C genotype) significantly increases the risk of colorectal cancer in Japanese individuals.
Kuriki et al. (2005) conducted a case-control in Colorectal cancer (n=366). CD36 C/C genotype and moderate meat consumption vs. CD36 A/A genotype and low meat consumption was evaluated on Risk of colorectal cancer (OR 8.30, 95% CI 2.15-32.00). The CD36 C/C genotype with moderate meat consumption increased colorectal cancer risk compared to the A/A genotype with low meat consumption (OR 8.30; 95% CI 2.15-32.00).
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